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Polysorbate 80 Controls Morphology, Structure and Stability of Human Insulin Amyloid-Like Spherulites
[article]
2021
bioRxiv
pre-print
Amyloid protein aggregates are not only associated with neurodegenerative diseases and may also occur as unwanted by-products in protein-based therapeutics. Surfactants are often employed to stabilize protein formulations and reduce the risk of aggregation. However, surfactants alter protein-protein interactions and may thus modulate the physicochemical characteristics of any aggregates formed. Human insulin aggregation was induced at low pH in the presence of varying concentrations of the
doi:10.1101/2021.08.10.455855
fatcat:4qiasce5wnfpppmwwcgfwyf4om