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Mathematical modelling of oxygen gradients in stem cell-derived liver tissue
2021
PLoS ONE
A major bottleneck in the study of human liver physiology is the provision of stable liver tissue in sufficient quantity. As a result, current approaches to modelling human drug efficacy and toxicity rely heavily on immortalized human and animal cell lines. These models are informative but do possess significant drawbacks. To address the issues presented by those models, researchers have turned to pluripotent stem cells (PSCs). PSCs can be generated from defined genetic backgrounds, are
doi:10.1371/journal.pone.0244070
pmid:33556073
fatcat:qlq4a5tn4rehvcm3zpw7usio2y