Her-2/Neu Overexpression in Invasive Bladder Carcinoma Among a Cohort of Egyptian Patients
World Journal of Nephrology and Urology
Bladder cancer is one of the commonest malignancies among Egyptian population with high morbidity and mortality rates. Human epidermal growth factor receptor-2 (Her-2/Neu) seems to play role in the pathogenesis and prognosis of bladder carcinomas; however, its expression and prognostic significance were variable between different studies. This study evaluates the status of Her-2/Neu protein expression in invasive carcinomas of the bladder among a cohort of Egyptian patients using
... istry (IHC) and determines its relation to some clinicopathological factors. Methods: A number of 32 invasive bladder carcinoma patients treated with radical cystectomy were enrolled. Tumor sections were immunostained using anti-Her-2/Neu antibody and were evaluated by at least two pathologists. Statistical analysis was carried out with the Statistical Software Package Standard (SPSS). Results: Her-2/Neu membranous staining was observed in 20 carcinomas (62.5%). Statistical analysis revealed significant direct association between Her-2/Neu and both increasing grade of carcinoma (P = 0.001) and depth of tumor invasion (P ≤ 0.001). Patient's gender, histological subtype and the presence of bilharzial cystitis did not have any significant association with Her-2/Neu overexpression. Conclusion: Her-2/Neu immunopositivity was observed in a considerable proportion of cases with association to adverse prognostic factors, thus patients with high-grade, deeply invasive carcinoma of the bladder may benefit from Her-2/Neu-targeted therapies after radical cystectomy.