TiCl 4 : An efficient catalyst for one-pot synthesis of 1,2-dihydro-1-aryl-naphtho-[1,2- e ][1,3]oxazin-3-one derivatives and their drug score analysis

Raveendra Hunnur, Ravindra Kamble, Atukuri Dorababu, B. Sunil Kumar, Chinna Bathula
2017 Arabian Journal of Chemistry  
Multi-component, economical and efficient synthesis of 1,2-dihydro-1-aryl-naphtho[1,2-e][1,3]-oxazin-3-one derivatives (4a-k) with an excellent yield is described through a one-pot condensation of b-naphthol, aromatic aldehydes and urea in presence of catalytic amount of TiCl 4 (10 mol%) under conventional heating and microwave irradiation. The role of catalyst in the conversion of reactants to the final compounds is described. All the compounds have been characterized by spectral (IR, 1 H, 13
more » ... NMR and Mass) and analytical data. The pharmacological parameters of title compounds were also analyzed for their bioavailability by Osiris property explorer. ª 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.
doi:10.1016/j.arabjc.2013.06.028 fatcat:ebvyubt4areahbep6qxfnhz7dq