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TiCl 4 : An efficient catalyst for one-pot synthesis of 1,2-dihydro-1-aryl-naphtho-[1,2- e ][1,3]oxazin-3-one derivatives and their drug score analysis
Arabian Journal of Chemistry
Multi-component, economical and efficient synthesis of 1,2-dihydro-1-aryl-naphtho[1,2-e][1,3]-oxazin-3-one derivatives (4a-k) with an excellent yield is described through a one-pot condensation of b-naphthol, aromatic aldehydes and urea in presence of catalytic amount of TiCl 4 (10 mol%) under conventional heating and microwave irradiation. The role of catalyst in the conversion of reactants to the final compounds is described. All the compounds have been characterized by spectral (IR, 1 H, 13doi:10.1016/j.arabjc.2013.06.028 fatcat:ebvyubt4areahbep6qxfnhz7dq