The Efficacy of Infliximab in Refractory Uveitis

Joon Hyung Kim, Dong Wook Lee, Nam Chun Cho
2016 Journal of the Korean Ophthalmological Society  
Purpose: To investigate the effectiveness of infliximab as treatment for refractory uveitis that recurred in spite of immunosuppressive agents. Methods: Thirty patients who were treated for refractory uveitis from 2002 to 2011 were included in this study. We retrospectively reviewed the medical records of 15 patients who were treated with Infliximab and 15 patients not treated with Infliximab. Infliximab was injected intravenously (5 mg/kg) 3 times every 4 weeks, and the patients were
more » ... p at 1 week, 2 weeks, and every month thereafter. Anterior chamber cell reaction with a score greater than 0.5+ was defined as recurrence of uveitis. Results: Among 15 patients treated with Infliximab, only one showed no response to the medication. The recurrence rate was significantly higher in patients receiving Infliximab treatment (1.1 ± 0.2 times) than in those not receiving Infliximab treatment (3.1 ± 0.3 times) (p=0.022). Conclusions: Infliximab can be used effectively on patients with refractory uveitis. However, a future prospective randomized study is needed to demonstrate the effectiveness of Infliximab and to determine an accurate protocol regarding dosage and number of injections. J Korean Ophthalmol Soc 2016;57(1):50-55
doi:10.3341/jkos.2016.57.1.50 fatcat:hxg3h7y3xbcjbnbpdk6viag4qq