Mass spectrometry proteomic diagnosis: enacting the validation paradigm [article]

Bart J. A. Mertens, M. E. de Noo, R. A. E. M. Tollenaar, A. M. Deelder
2005 arXiv   pre-print
This paper presents an approach to the evaluation and validation of mass spectrometry data for construction of an 'early warning' diagnostic procedure. We describe implementation of a designed experiment and place emphasis on the consistent and correct use of validation based evaluation - which is a key requirement to achieve unbiased assessment of the ability of mass spectrometry data for diagnosis in this setting. Strict adherence to validation as a scientific principle will however typically
more » ... imply that the analyst must make choices. Like all choices in statistical analysis, validation comes at a cost! We present a detailed and extensive discussion of the issues involved and propose that much greater emphasis and requirement for validation would enter clinical proteomic science.
arXiv:math/0510188v1 fatcat:wjapty5dpnbc3jllkyhanzip7q