Modulating Effects of Korean Ginseng Saponins on Ovarian Function in Immature Rats

Wook-Joon Yu, Beom-Jun Lee, Sang-Yoon Nam, Deok-Chun Yang, Young-Won Yun
2003 Biological and Pharmaceutical Bulletin  
The modulating effects of Korean ginseng saponins on ovarian functions were investigated in immature rats superovulated with pregnant mare serum gonadotropin (PMSG). A single dose of 1 mg (0.1 ml/head) of Korean ginseng total saponin (GTS), Korean ginseng protopanaxatriol saponin (GPT), Korean ginseng protopanaxadiol saponin (GPD), or ginsenoside-Rb 1 (Gin-Rb 1 ) was intravenously injected via jugular vein catheter three times at 1 h (early follicular phase), 25 h (middle follicular phase), and
more » ... licular phase), and 50 h (late follicular phase) after 30 IU PMSG administration. GPD and Gin-Rb1 significantly suppressed excessive ovulatory response caused by PMSG (pϽ0.05). All Korean ginseng saponins significantly improved oocyte quality by decreasing the proportion of abnormal oocytes (pϽ0.05). Gin-Rb 1 significantly decreased preovulatory serum levels of androgens and 17b b-estradiol, while GPD increased preovulatory serum progesterone level (pϽ0.05). GPD significantly the increased postovulatory serum progesterone level (pϽ0.05). These results provide strong evidence that Korean ginseng saponins have a curative effect on ovarian dysfunction caused by excessive stimulation with PMSG.
doi:10.1248/bpb.26.1574 pmid:14600404 fatcat:ruhtvrsjmzb3dd33gan3l3ze6i