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Mechanism of mTOR inhibitors mediated DDP resistance in pancreatic cancer through the mTOR pathway
2021
Romanian Biotechnological Letters
Mechanism of mTOR inhibitor rapamycin mediated cis-Dichlorodiamine Platinum (DDP) resistance in pancreatic cancer was explored. PANC-1, BxPC-3 and SW1990 cells cultured were used for wound healing assay and MTT assay. Western blot was used to see expression levels of mTOR signal pathway associated protein PI3K, p-PI3K, AKT, p-AKT, mTOR, and p-mTOR inhibited by rapamycin. The pancreatic cancer cell lines of PANC-1, BxPC-3 and SW1990 were all resistant to DDP. After the application of DDP
doi:10.25083/rbl/26.2/2476.2482
fatcat:i5vsr572dnawtprx3x6f4wn2ki