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Tal1 Transgenic Expression Reveals Absence of B Lymphocytes
2006
Cancer Research
TAL1 oncogene encodes a helix-loop-helix transcription factor, Tal1, which is required for blood cell development, and its activation is a frequent event in T-cell acute lymphoblastic leukemia. Tal1 interacts and inhibits other helix-loop-helix factors such as E47 and HEB. To investigate the function of Tal1 in B cells, we generated EM-TAL1 transgenic mouse line, expressing Tal1 in mouse B-cell lineage. Fluorescence-activated cell sorting (FACS) analysis of lymphocytes isolated from spleens of
doi:10.1158/0008-5472.can-06-0937
pmid:16778172
fatcat:geob7jaifvgcvaerxi24kn6qii