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A series of nitrofuran-based compounds were identified as inhibitors of estrogen signaling in a cell-based, high-throughput screen of a diverse library of small molecules. These highly related compounds were subsequently found to inhibit topoisomerase II in vitro at concentrations similar to that required for the inhibition of estrogen signaling in cells. The most potent nitrofuran discovered is f10-fold more active than etoposide phosphate, a topoisomerase II inhibitor in clinical use. Thedoi:10.1158/0008-5472.can-07-0393 pmid:17483360 fatcat:b7joiefbx5hn5eqacr5vai766e