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Bone marrow mononuclear cells (BMMCs) transplantation is a potential therapy for acute liver failure; however, its therapeutic efficacy requires improvement. Methods: We established a murine acute liver failure model induced by CCl4 administration. The effect of BMMCs transplantation in combination with hepatocyte growth factor (HGF) was studied. Recipient mice were transfused with PKH26-labeled BMMCs (5×10 6 ) with HGF (50 ng/kg.d ×7 days) (BMMCs + HGF group). BMMCs only, HGF alone, and 0.9%doi:10.1016/s1201-9712(10)60057-4 fatcat:5edvtjp7wfblfkw77atiwfmnfa