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A genome-wide scan has revealed multiple conserved groups of neuropeptide genes in the nematode Caenorhabditis elegans Significance and context Much synaptic signaling in the nervous system is facilitated by specialized peptidergic neurotransmitters called neuropeptides. Neuropeptides function in neurotransmission primarily by modulating synaptic signaling through other, small-molecule, neurotransmitters, and exert their function through seven-span transmembrane receptors, although a sodiumdoi:10.1186/gb-2002-3-2-reports0010 fatcat:l3hfhuvrfjfutgzhbj2g2bio4y