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Characterizing intratumor heterogeneity (ITH) is crucial to understanding cancer development, but it is hampered by limits of available data sources. Bulk DNA sequencing is the most common technology to assess ITH, but mixes many genetically distinct cells in each sample, which must then be computationally deconvolved. Single-cell sequencing (SCS) is a promising alternative, but its limitations − e.g., high noise, difficulty scaling to large populations, technical artifacts, and large data setsdoi:10.1101/519892 fatcat:radxvlu7hndk3lwepn2a22xxkq