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Stat4 activation is involved in differentiation of type 1 helper (Th1) T cells. Although Stat4 is activated by interleukin (IL)-12 in both human and murine T cells, Stat4 is activated by interferon (IFN)-␣ only in human, but not murine, CD4 ؉ T cells. This species-specific difference in cytokine activation of Stat4 underlies critical differences in Th1 development in response to cytokines and is important to the interpretation of murine models of immunopathogenesis. Here, we sought to determinedoi:10.1074/jbc.275.4.2693 pmid:10644731 fatcat:fgegzr3hcbcjhmjqrquq3gy2fe