K.-H. Han, R.D. McConnell, J.P. Ferrance, J.P. Landers, A.B. Frazier
2004 2004 Solid-State, Actuators, and Microsystems Workshop Technical Digest   unpublished
This paper introduces a generic packaging approach for microfluidic systems. The 'integrated microfluidic interface' (IMI) provides a simple method for realizing complex arrangements of on-chip to off-chip fluid interconnects, optical windows, and general fluid control components such as pumps / valves into a single package. The fluid interconnects were designed for "one step" fabrication using stereolithography and post assembly of o-rings to ensure a tight seal. The normally open latex
more » ... y open latex microvalves had zero dead volume and were pneumatically actuated by a gauge pressure of ~400kPa. The IMI was demonstrated in a glass-based genetic sample preparation application in which the total analysis system contained microchannels and sub-compartments with different analytical functions. Optical windows in the IMI were utilized for an infrared mediated polymerase chain reaction compartment and for the fluorescence detection in the capillary electrophoresis compartment. The performance of the sample preparation system with the IMI was experimentally characterized, showing that this approach can provide a simple and reliable macro-micro interfacing solution for complex microfluidic systems.
doi:10.31438/trf.hh2004.49 fatcat:qazy6sxh4bfunbinhwz63diibu