Aim: A 6 month long study was undertaken to determine various hemato-biochemical profiles of indigenous goats (Capra hircus) in Bangladesh. Materials and methods: Blood samples were collected from goats of different ages of 5 Upazilla of Chittagong. A total of 120 goats (60 Black Bengal and 60 Jamnapari) having > 6 months of age were included. The whole blood was analyzed for hematology, and plasma and serum samples for biochemical analysis. Results: The study found higher number of RBC

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... /cumm) and PCV% in the goats of age 48 months and above (18.23 ± 1.89 and 28 ± 3.2) respectively. Besides, total protein was found higher (78.9 ± 14.5g/L) in the goats of 6-24 months of age. Significant increase (p<0.01) of the number of WBC (thousand/cumm), RBC (million/cumm), PCV% was observed in Black Bengal over Jamnapari goat. In contrast, WBC, lymphocytes, RBC, PCV, ALT, and AST were significantly (p<0.01) higher in Black Bengal than Jamnapari goat; whereas, monocyte, TP, Albumin, and Urea levels were significantly (p<0.01) higher in Jamnapari than Black Bengal goats. Conclusion: The results of the present study demonstrate the normal haemato-biochemical values of two local goat breeds. Present results stated some significant variation of parameters between two goats whereas some shows no significant variation at all.