Association between Circulating Adiponectin and Interleukin-10 Levels in Android Obesity: Effects of Weight Loss

M. R. Manigrasso, P. Ferroni, F. Santilli, T. Taraborelli, M. T. Guagnano, N. Michetti, G. Davì
2005 Journal of Clinical Endocrinology and Metabolism  
Objective: Adiponectin inhibits vascular inflammation and increases IL-10 mRNA expression in human macrophages. Thus, we investigated the possible relationship between plasma adiponectin and IL-10 levels and the effects of a diet-induced moderate weight loss on both cytokines. Patients and Study Design: Plasma adiponectin and IL-10 levels were analyzed in 64 android [body mass index (BMI), Ͼ28 kg/m 2 ; waist to hip ratio (WHR), Ն0.86] and 20 gynoid [BMI, Ͼ28 kg/m 2 ; WHR, Ͻ0.86] obese healthy
more » ... 86] obese healthy women. Android obese women (49 Ϯ 14 yr) had a mean BMI of 37.1 Ϯ 5.3 kg/m 2 , similar to that of gynoid obese women (49 Ϯ 11 yr; BMI, 33.4 Ϯ 2.6 kg/m 2 ). Twenty nonobese control women (46 Ϯ 11 yr; BMI, 25.2 Ϯ 2.2 kg/m 2 ) were also studied. In 15 android obese women, measurements were repeated after a 12-wk diet period (1200 kcal/d). Results: Median adiponectin [5.2 (range, 3.3-7.8) vs. 12.1 (9.7-13.9) vs. 15.0 (12.6 -18.2) g/ml; P Ͻ 0.0001] and IL-10 [1.8 (1.2-3.3) vs. 3.5 (2.9 -4.3) and vs. 4.1 (3.5-4.8) pg/ml; P Ͻ 0.0001] levels were lower in android vs. gynoid vs. nonobese women. Among android obese women, low adiponectin levels were independently related (P Ͻ 0.0001) to decreased IL-10 levels, independently of BMI, WHR, or insulin resistance. No significant change in either median adiponectin or IL-10 levels was observed after body weight reduction (8 Ϯ 4 kg; P Ͻ 0.01), although percent changes in adiponectin paralleled those in IL-10 (P Ͻ 0.05). Conclusions: Android obesity is associated with a concomitant reduction of IL-10 and adiponectin levels. However, the antiinflammatory status of obesity might require prolonged periods of energyrestricted diets to revert to normal. (J Clin Endocrinol Metab 90: 5876 -5879, 2005)
doi:10.1210/jc.2005-0281 pmid:16030165 fatcat:ackqnwl7zffo5aqnlylm5o2isu