The change of physical-chemical factors of the local interaction with the human body as the basis for the creation of materials with new properties alekSandr l. urakov § Izhevsk State Medical Academy, Izhevsk (Russia) § urakoval@live.ru Abstract The study of the dynamics of liquid, soft and hard tissues of the human body by physical contact for several minutes with vascular catheters, gastric, intestinal and pleural probes, tablets, and aqueous solutions of drugs subject to certain

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... ical factors of local interaction. It is shown that the interaction with these medical devices, the condition of the skin, subcutaneous fat, teeth enamel, established dental structures and mucous membranes of the oral cavity, esophagus, stomach, eyes, as well as the state of the venous blood inside the vessels within the vascular catheters and other devices for storing and injecting blood and infusion solutions, is largely determined by the preservation of the natural values of the physicalchemical characteristics of these tissues. It is established that medical devices, differing in their temperature, gas composition, osmotic and/or the acid activity of the relevant characteristics of body parts in contact with them, change their condition: the stronger, the greater the difference in their physical-chemical activity and the longer continuous interaction. In this regard, an assumption that the purposeful change of physical-chemical characteristics of the standard ("old") materials (in other words, the known substances) that underlie the production of products in solid and liquid state, allows us to get "new" structures and materials. It is shown that purposeful giving old materials new "old" materials with new physical and chemical properties and their use for the production of tablets and solutions from the "old" and well-known medicines can turn even very "old" medicines in very "young" (moreover, even very fashionable), and new drugs with unprecedented (even fantastic) pharmacological activity and with new mechanisms of action. (since 1988) in Izhevsk, Russia. Since then 36 doctors and biologists from the department have successfully defended their dissertations (PhD) under the supervision of Prof. Urakov. He is author or coauthor of 130 patents, 15 books and more than 250 scientific papers.