P5867COMBINE OCT and FFR assessment of non culprit lesions to better predict adverse event outcomes in diabetes mellitus patients. Rationale, design and initial OCT results

E. Kedhi, B. Berta, T. Roleder, M.W. Kennedy, E. Fabris, A.J. Ijsselmuiden, H. Nef, S. Reith, J. Escaned, F. Alfonso, N. Van Royen, W. Wojakowski (+2 others)
2017 European Heart Journal  
and 10.7 ng/ml vs. 5.5 ng/ml (p=0.0001), respectively, IGFBP-7: median 35.1and 32.7 ng/ml vs. 25.2 ng/ml (p=0.0001), respectively,). The value of ≥8.6 ng/ml (AUC=0.93, 95% CI: 0.889-0.964) for Gal-3 and the value of ≥38.7 ng/ml for IGFBP-7 (AUC=0.703, 95% CI=0.648-0.753) have been assigned as a cut-off point with comparable diagnostic quality (difference between areas=0.024, 95% CI: -0,055-0,104, p=0,552). Gal-3 concentrations correlate with a degree of coronary vessels changes advancement
more » ... g/ml in 3-vessel disease vs. 7.4ng/ml, p=0.003), while IGFBP-7 does not. Significant correlations between IGFBP-7 and Gal-3 concentrations and cIMT values were found. In the group of MI patients who died during the follow-up, we found a significantly higher concentration of Gal-3 (20.0ng/ml vs 8.0ng/ml, p=0.0005) and cIMT values (common carotid artery (CCA): 1.4±0.4 mm vs. 1.0±0.3 mm, p=0.03; carotid bulb (CB): 2.3±0.5 mm vs. 1.9±0.4 mm, p=0.009), but not IGFBP-7 concentration. In the model of multivariate logistic regression analysis the variables influencing the appearance of CAD were: age >65 years, male, IGFBP 7 concentration >38.7ng/mL, Gal-3 concentration >6.1 ng/ml (p=0.0008, OR=1,30, 95% CI: 1,12-1,52) and cIMT values in CB >0.9mm. In the second model -the variables influencing the mortality after MI during follow-up were: age>65 years, Gal-3 concentration >8.7 ng/ml, IMT values and plaque occurrence in CB, previous MI and EF<40%. Conclusions: Both Gal-3 and IGFBP-7 are independent risk factors of CAD occurrence, but only Gal-3 concentration and cIMT values are markers of CAD advancement. Gal-3 concentration (but not IGFBP-7) and IMT values in CB were an independent predictive indicators of increased risk of all-cause mortality in patients after MI during mid-term follow-up.
doi:10.1093/eurheartj/ehx493.p5867 fatcat:kxwixwvxqbcn7i5a7plccpwsye