Effects of Liandou Qingmai Recipe () on Endothelin-1, Nitric Oxide, Interleukin-6 and Interleukin-10 Levels in Patients with Coronary Heart Disease

Hong-jun ZHU, Shu LU, Wei SU, Shao-yu GONG, Zhi-bin ZHANG, Ping LI, Hui-yuan WEI, Qing-you YANG, Hong TANG, Cheng-xia XIA, Ming ZHU
2011 Journal of Traditional Chinese Medicine  
Objective: To observe effects of Liandou Qingmai Recipe ( ) on endothelin-1 (ET-1), nitric oxide (NO), interleukin-6 (IL-6) and IL-10 levels in patients with coronary heart disease. Methods: Total 101 cases with coronary heart disease were randomly divided into a treatment group (n=45) treated by Liandou Qingmai Recipe and a standard treatment group (control group, n=56), with a normal group of 16 health persons set up. Changes of ET-1, NO, IL-6 and IL-10 levels were measured before treatment
more » ... before treatment and after treatment for two weeks. And the data were analyzed by SPSS 16.0 statistic software. Results: Before treatment, the levels of ET-1, IL-6 and IL-10 levels were significantly higher and NO was significantly lower in the patients with coronary heart disease than those in the normal group (90.7±12.7 ng/L vs 41.8±13.5 ng/L, 9.17±0.18 ng/L vs 1.10±0.08 ng/L, 1.94±0.26 ng/L vs 1.09±0.06 ng/L, and 92.2±17.7 mol/L vs 124.5±27.2 mol/L; all P<0.05), with no significant differences in the levels of ET-1, NO, IL-6 and IL-10 between the treatment group and the control group (P>0.05); After treatment, ET-1 and IL-6 significantly decreased in the treatment group and the control group, and NO increased in the treatment group; And IL-6 level was significantly lower and NO level was higher in the treatment group than those in the control group (4.48±1.22 ng/L vs 5.13±1.85 ng/L, 117.4±22.3 μmol/L vs 92.4±17.1 μmol/L; both P<0.05); There was a positive correlation between IL-6 and IL-10, and a negative correlation between both P<0.05). Conclusion: Liandou Qingmai Recipe can decline IL-6, IL-10 and ET-1 levels, and raise NO level in patients with coronary heart disease on the basis of standard treatment, so as to inhibit endothelial inflammatory response, improve vascular endothelial function, with stronger anti-AS action; And vascular endothelial lesion is related with inflammatory response.
doi:10.1016/s0254-6272(11)60035-6 fatcat:eajclpy3grewxfx3bxw45my3mq