Noncirrhotic portal hypertension (NCPH) is an uncommon liver disease of unknown origin, increasingly described in HIV-infected adults. Prolonged antiretroviral exposure, in particular to didanosine, and thrombophilic predisposition have been suggested as potential pathogenic factors. Data are scant in children. We describe a 10-year-old HIV-infected girl with NCPH who presented with progressive spleen enlargement and variceal bleeding. A C C E P T E D supports the proposed hypothesis of a

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... ogical role of prothrombotic state in development of NCPH. NCPH should be considered an emerging non-AIDS comorbidity in pediatric HIV infection that is likely related to treatment, particularly with didanosine, and other factors.