Understanding the Molecular Mechanisms of Asthma through Transcriptomics

Heung-Woo Park, Scott T. Weiss
2020 Allergy Asthma and Immunology Research  
The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk RNA sequencing, as well as recent advances in biostatistics based on machine learning approaches provides a quick and effective way of identifying novel genes and pathways related to asthma, which is a heterogeneous disease with diverse pathophysiological mechanisms. In this manuscript, we
more » ... fly review how to analyze transcriptome data and then provide a summary of recent transcriptome studies focusing on asthma pathogenesis and asthma drug responses. Studies reviewed here are classified into 2 classes based on the tissues utilized: blood and airway cells.
doi:10.4168/aair.2020.12.3.399 pmid:32141255 pmcid:PMC7061151 fatcat:4u7pwjzpunav7i3fcsj2jnipqu