Targeted prostate biopsy and MR-guided therapy for prostate cancer

David A. Woodrum, Akira Kawashima, Krzysztof R. Gorny, Lance A. Mynderse
<span title="2016-02-24">2016</span> <i title="Springer Nature"> Abdominal Radiology </i> &nbsp;
Prostate cancer is the most commonly diagnosed noncutaneous cancer and second-leading cause of death in men. Many patients with clinically organ confined prostate cancer undergo definitive treatment of the whole gland including radical prostatectomy, radiation therapy and cryosurgery. Active surveillance is a growing alternative option for patients with documented low volume, low grade prostate cancer. With recent advances in software and hardware of MRI, multiparametric MRI of the prostate has
more &raquo; ... been shown to improve the accuracy in detecting and characterizing clinically significant prostate cancer. Targeted biopsy is increasingly utilized to improve the yield of MR detected, clinically significant prostate cancer and to decrease in detection of indolent prostate cancer. MR guided targeted biopsy techniques include cognitive MR fusion TRUS biopsy, in-bore transrectal targeted biopsy using robotic transrectal device, and in-bore direct MR guided transperineal biopsy with a software based transperineal grid template. In addition, advances in MR compatible thermal ablation technology allow accurate focal or regional delivery of optimal thermal energy to the biopsy proved, MRI detected tumor, utilizing cryoablation, laser ablation, high intensity focused ultrasound ablation under MR guidance and real time or near simultaneous monitoring of the ablation zone. Herein we present a contemporary review of MR guided targeted biopsy techniques of MR detected lesions as well as MR guided focal or regional thermal ablative therapies for localized naïve and recurrent cancerous foci of the prostate.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1007/s00261-016-0681-3</a> <a target="_blank" rel="external noopener" href="">pmid:26907717</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC5811219</a> <a target="_blank" rel="external noopener" href="">fatcat:zeey6g2ljjakhofx3rhujsfxc4</a> </span>
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