Aim: Aim of Study is to find out the prevalence of depression among HCV patients and to find out correlation between depression, risk factors, associated diseases and complications develop among chronic HCV patients. Methodology: it is a Cross-sectional Study conducted in July to August 2019 in Liver Opd and ward Muhammad medical college Mirpurkhas. 53 Patients having hepatitis for more than 6 months were included in the study while newly diagnosed cases were excluded. Data Collected through

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... e to face interview was conducted by using closed ended questionnaire (PH-8). Data entered and analysis done by SPSS version 24. Results: 11.3% were Mildly Positive for Depression, 43.3% were moderately positive, 37.7% were moderately sever positive while only 7.5% were severely positive. Overall depression was found in age group of 41-50 & 51-60. While out of total depressed patient 69.9% patients were associated with other diseases. From Patients who develop the complications 7 presents was with mild depression, 11 presents was with moderate depression & 54% was with severe depression. From patients who were taking ribavirin out of which 19.4% develop mild depression, 48.4% develop moderate depression and 32.2% develop moderately severe depression. Out of patients with mild depression no one was taking antidepressants while with moderate depression 8% were getting antidepressants, with moderately severe depression 12% were taking antidepressants, 50% patients with severe depression were getting antidepressant treatment. Conclusion: We concluded that all the patients with HCV were having some degree of depression. The prevalence of depression was found to be Mild depression 11.3%, Moderate depression 43.3%, moderately severe depression 37.5%, and severe depression 7. While 37.3% patient develop further complications like hepatic encephalopathy etc. Keywords:< [...]