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One of the key questions concerning glutamate toxicity is how a transient NMDA exposure can lead to a delayed death of neurons. To address this issue, we performed whole-cell recording on acutely isolated hippocampal CA1 neurons to monitor the membrane response after NMDA exposure. Transient NMDA exposure (100 M, 10 min) induced an inward current (postexposure current; I pe ) which was associated with a Ca 2ϩand Na ϩ -permeable cation conductance. I pe continuously increased (in the absence ofdoi:10.1523/jneurosci.17-11-04032.1997 pmid:9151719 fatcat:w2eolscxxzfahf6aolvh4476ti