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Identifying constraints that govern cell behavior: a key to converting conceptual to computational models in biology?
2003
Biotechnology and Bioengineering
Cells must abide by a number of constraints. The environmental constraints of cellular behavior and physicochemical limitations affect cellular processes. To regulate and adapt their functions, cells impose constraints on themselves. Enumerating, understanding, and applying these constraints leads to a constraint-based modeling formalism that has been helpful in converting conceptual models to computational models in biology. The continued success of the constraint-based approach depends upon
doi:10.1002/bit.10849
pmid:14708117
fatcat:zhsoh3jbonaivbdzwv7euujvke