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Effects of a thromboxane A2 analogue and prostacyclin on lung fluid balance in newborn lambs
We have previously shown that the pulmonary venoconstriction produced by a stable thromboxane A 2 analogue (STAJ is attenuated by prostacyclin (PGIi), but PGI, increases the STA 2 -induced edema. The present study was designed to determine the effects of STA 2 and PGI 2 on the fluid balance in isolated blood-perfused newborn lamb lungs. Vascular permeability was evaluated by use of the fluid filtration coefficient (Kf) and the osmotic reflection coefficient for total proteins (cr,doi:10.1161/01.res.65.5.1409 pmid:2509097 fatcat:o34fpex4jzf6jbfqsuagnx7vge