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Major finding: SERPINE2 and SLPI drive metastasis by enabling breast cancer cells to form vascular-like networks. Approach: A mouse model of breast cancer heterogeneity was generated using molecular barcoding. Impact: Anticoagulant-driven vascular mimicry supports tumor perfusion and enhances intravasation.doi:10.1158/2159-8290.cd-rw2015-071 fatcat:zqpn62gwx5ekrepd3ez3xrqrmu