Vascular Mimicry Promotes Breast Cancer Metastasis

2015 Cancer Discovery  
Major finding: SERPINE2 and SLPI drive metastasis by enabling breast cancer cells to form vascular-like networks. Approach: A mouse model of breast cancer heterogeneity was generated using molecular barcoding. Impact: Anticoagulant-driven vascular mimicry supports tumor perfusion and enhances intravasation.
doi:10.1158/ fatcat:zqpn62gwx5ekrepd3ez3xrqrmu