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Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial
ABSTRACTBackgroundRTS,S is the leading malaria vaccine candidate, but only confers partial efficacy against malaria in children. RTS,S is based on the major Plasmodium falciparum sporozoite surface antigen, circumsporozoite protein (CSP). The induction of anti-CSP antibodies is important for protection, however, it is unclear how protective antibodies function.MethodsWe quantified the induction of functional anti-CSP antibody responses in healthy malaria-naïve adults (N=45) vaccinated withdoi:10.1101/851725 fatcat:v356ouszdzb57ltrphfuv5bxgi