P3.02c-003 TAX-TORC: The Novel Combination of Weekly Paclitaxel and the Dual mTORC1/2 Inhibitor AZD2014 for the Treatment of Squamous NSCLC

Matthew Krebs, James Spicer, Nicola Steele, Denis Talbot, Michael Brada, Richard Wilson, Robert Jones, Bristi Basu, Joanna Dawes, Mona Parmar, Beth Purchase, Alison Turner (+4 others)
2017 Journal of Thoracic Oncology  
enroll in a phase I dose-escalation study (standard 3+3 design) of SASP in combination with CDDP and pemetrexed (PEM) as first-line treatment. Patients receive SASP daily as well as CDDP (75 mg/m 2 ) and PEM (500 mg/m 2 ) on day 1 of a 21-day cycle. The primary end point is the percentage of patients who experience doselimiting toxicity (DLT) between administration of the first dose of SASP (day 1) and day 21. Results: From April 2015 to January 2016, 15 patients were enrolled in the study
more » ... d in the study (mean age, 64 years; age range, 42e74 years; male/female ratio, 10/5; ECOG performance status 0/1 ratio, 6/9). Immunohistochemical staining of tumor biopsy specimens revealed that the proportion of CD44v-positive cells was >10% in 9 patients before SASP treatment. No DLT was observed in the first three patients treated at SASP dose level 1 (500 mg TID) or those treated at dose level 2 (1000 mg TID). At dose level 3 (1500 mg TID), two of three patients experienced a DLT (anorexia of grade 3). We enrolled additional patients at dose level 2 and two of the total of five patients treated at this dose level experienced DLTs (hypotension or pneumonitis, each of grade 3). To confirm the safety of dose level 1, we enrolled additional patients at this dose level and one of the total of six patients treated at this dose level experienced DLTs (AST and ALT elevation, each of grade 3). Exposure of SASP following oral administration varied markedly among individuals according to ABCG2 and NAT2 genotypes as previously reported. Conclusion: SASP 500 mg TID was the recommended dose when administered with CDDP plus PEM.
doi:10.1016/j.jtho.2016.11.1798 fatcat:bimoi5nkyrdztnhavrrelfhnfm