Retinol May Promote Fluorouracil-Suppressed Healing of Experimental Intestinal Anastomoses

Jan Willem D. de Waard
1995 Archives of Surgery  
O b je c tiv e s : To examine the effects of perioperative ad ministration of fluorouracil on healing variables of in testinal anastomoses and to explore ways to promote re pair under these conditions. D esign: Seven-day, prospective randomized experimen tal trial. S e ttin g : Animal research laboratory. A n im a ls : Male young-adult Wistar rats after resection and anastomosis of both ileum and colon. In te rve n tio n s: Random assignment to groups receiv ing placebo, daily fluorouracil (20
more » ... y fluorouracil (20 mg/kg per day, intraperi to ne ally), daily fluorouracil plus retinol palmitate (5000 lU/kg per day, orally), daily fluorouracil plus in terleukin-2 (2X106 IU/kg per day, subcutaneously), or daily fluorouracil plus granulocyte macrophage colonystimulating factor on the first 4 days after operation (20 jxg/kg per day, intraperitoneally). M a in O utcom e M e a su re s: Anastomotic bursting pres sure, breaking strength, hydroxyproline content, and ex vivo collagen synthetic capacity.
doi:10.1001/archsurg.1995.01430090045017 pmid:7661680 fatcat:yg5nfhbiuzf53pfakq2wg3wybi