Clove oil, Thyme oil at three concentrations (5 cm 3 , 2.5 cm 3 and 1.5 cm 3 / colony) and Ascorbic acid at 3 concentrations (5%, 2.5% and 1.5% /colony) an natural were applied against stone brood disease infesting honeybee colonies which caused by Aspergillus flavus at new lands of Noubaria region, Behiera Governorate, Egypt. The infested honeybee colonies were treated with the tested materials at three concentrations during the summer season, of 2019. The obtained results indicated that all

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... sted materials were effective against the stone brood disease under field conditions. The average reduction of infection reached 84.40, 78,46 and 63.76% respectively after using clove oil at the rate (5,2.5 and 3 cmP 3 P / colony), respectively. Ascorbic acid treatments registered 83.26, 75.16 and 68.73% reduction in stone brood disease at the concentration (5, 2.5 and 1.5%) respectively. Thyme oil treatments recorded 77.36, 69.1 and 60.86% reduction in stone brood disease at the concentrations (5,2.5 and 1.5 cmP 3 P / colony) respectively.