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The spread of cancer from a primary tumor to distant organ sites is the most devastating aspect of malignancy. Dissemination to specific organs depends upon blood flow patterns and characteristics of the distant organ environment, such as the vascular architecture, stromal cell content, and the biochemical milieu of growth factors, signaling molecules, and metabolic substrates, which can be permissive or antagonistic to metastatic colonization. Metastatic tumor cells possess intrinsic cellulardoi:10.1146/annurev-cancerbio-041916-064715 fatcat:dvpfegroxfgxzivtqhmq4koy4a