Persistent organic pollutants (POPs) are chemicals that persist in the environment, bioaccumulate through the food chain, and exhibit toxic effects that threaten the health of humans and animals alike. The potential influence of POPrelated air pollution on male reproductive outcomes has attracted increasing interest in the scientific community and among policymakers and the public. Therefore, epidemiological studies on fertility should examine the impact of chronic exposure to POPs via

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... n. The objective of this review is to present and discuss the available evidence linking the exposure to airborne POPs to male reproductive health problems. This study focuses on the air concentrations, biomarkers, and potential effects on the male reproductive health of two classes of POPs: the industrial polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). Although the association between atmospheric pollutants and male reproductive health has been extensively investigated, particularly in relation to semen quality and endocrine outcomes, the molecular mechanisms of action, the adverse effects, and the dose-response relationships for many of these chemicals remain poorly understood. No systematic screening of common chemicals for negative endocrine effects is currently underway, and many questions remain regarding the impact on male reproductive health of exposures to these POPs. This review presents the air concentrations, biomarkers, and adverse male reproductive effects of PCBs and PBDEs pollutants. Given the dearth of information on this topic in the literature, studies are clearly needed to assess how pre-and post-natal exposure to airborne PCBs and PBDEs affects the male reproductive system. Future studies must also identify aerosols and airborne POPs that have a significant impact on male reproductive health and the pathways responsible for those effects.