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Certain antibody Fab fragments directed against the C terminus of outer surface protein B (OspB), a major lipoprotein of the Lyme disease spirochete, Borrelia burgdorferi, have the unusual property of being bactericidal even in the absence of complement. We report here x-ray crystal structures of a C-terminal fragment of B. burgdorferi OspB, which spans residues 152-296, alone at 2.0-Å resolution, and in a complex with the bactericidal Fab H6831 at 2.6-Å resolution. The H6831 epitope isdoi:10.1074/jbc.m412842200 pmid:15713683 fatcat:wx3w6olhgvaoriuqdyy6itkdtm