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The expression of a variant prostate-specific antigen in human prostate
Cancer Epidemiology, Biomarkers and Prevention
Although a splicing variant of prostate specific antigen (PSA-v) mRNA has been described previously, whether its protein (PSA-v or PSA-related protein 1, i.e., PSA-RP1) is actually expressed in human prostate cells remains elusive. We report that PSA-v protein is expressed in prostatic epithelia of both cancerous and benign tissues. Also, secreted PSA-v can be detected in the medium of a prostate cancer (PCa) cell line. Consistently, PSA-v mRNA is exclusively expressed in benign luminalpmid:11895882 fatcat:js26thadvfhhnbusiribrxcbpu