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The Clinical Meaning of Histamine Skin Reactivity
Journal of Allergy & Therapy
The definition of the "atopic state", i.e. subjects presenting at least one skin wheal with a minimum diameter of 3 mm induced by an allergen skin-prick test (ASPT), is based on the assumption that wheal size depends entirely on the amount of histamine produced in the antigen-antibody reaction. Several epidemiological studies have, however, demonstrated that an ASPT-elicited wheal is heavily modulated by "histamine skin reactivity" (HSR), i.e. the size of the wheal induced by a prick testdoi:10.4172/2155-6121.1000227 fatcat:7eabrs3uxndzvlniaho4bhnhsa