Arterial baroreceptors mediate the inhibitory effect of acute increases in arterial blood pressure on thirst

Sean D. Stocker, Edward M. Stricker, Alan F. Sved
2002 American Journal of Physiology. Regulatory Integrative and Comparative Physiology  
Arterial baroreceptors mediate the inhibitory effect of acute increases in arterial blood pressure on thirst. Am J Physiol Regulatory Integrative Comp Physiol 282: R1718-R1729, 2002; 10.1152/ajpregu.00651.2001.-The present study sought to determine whether arterial baroreceptor afferents mediate the inhibitory effect of an acute increase in arterial blood pressure (AP) on thirst stimulated by systemically administered ANG II or by hyperosmolality. Approximately 2 wk after sinoaortic
more » ... oaortic denervation, one of four doses of ANG II (10, 40, 100, or 250 ng ⅐ kg Ϫ1 ⅐ min Ϫ1 ) was infused intravenously in control and complete sinoaortic-denervated (SAD) rats. Complete SAD rats ingested more water than control rats when infused with 40, 100, or 250 ng ⅐ kg Ϫ1 ⅐ min Ϫ1 ANG II. Furthermore, complete SAD rats displayed significantly shorter latencies to drink compared with control rats. In a separate group of rats, drinking behavior was stimulated by increases in plasma osmolality, and mean AP was raised by an infusion of phenylephrine (PE). The infusion of PE significantly reduced water intake and lengthened the latencies to drink in control rats but not in complete SAD rats. In all experiments, drinking behavior of rats that were subjected to sinoaortic denervation surgery but had residual baroreceptor reflex function (partial SAD rats) was similar to that of control rats. Thus it appears that arterial baroreceptor afferents mediate the inhibitory effect of an acute increase in AP on thirst stimulated by ANG II or hyperosmolality. water intake; angiotensin II; hyperosmolality
doi:10.1152/ajpregu.00651.2001 pmid:12010754 fatcat:oyxy3gd7d5am5ostpvsyed4yey