State-of-the-Art of the Clinical use of Stem Cells from Deciduous Teeth: A Review

Gislaine Cristina dos Santos Silva Souza, University Center North Paulista (Unorp), Graduate in Dentistry, São José do Rio Preto – SP, Brazil., Idiberto José Zotarelli-Filho, Elias Naim Kassis, Post graduate and continuing education (Unipos), Postgraduate in dentistry, São José do Rio Preto SP, Brazil., University Center North Paulista (Unorp), Graduate in Dentistry, São José do Rio Preto – SP, Brazil.
2021 MedNEXT Journal of Medical and Health Sciences  
In recent years, mesenchymal stem cells derived from dental tissue have gained popularity for applications in tissue engineering and regenerative medicine. Objective: To present the main considerations about stem cells of primary teeth, as well as the importance of their clinical application. Methods: Experimental and clinical studies were included (case reports, retrospective, prospective and randomized studies), following the rules of systematic review-PRISMA. The search strategy was
more » ... on Medline / Pubmed, Web Of Science, ScienceDirect Journals (Elsevier), Cochrane Library, Harvard Library, Scopus, and OneFile (Gale). Major findings and Conclusion: Dental pulp stem cells from primary teeth have very promising properties and potential for bone TE; however, based on these findings and the well-known restrictions in stem cell research, it may be beneficial to at least standardize the methods currently used in animal models based on the bone defect to heal, in order to achieve a higher level of reliability results, enabling safe clinical use.
doi:10.34256/mdnt2113 fatcat:giijzipganfsrjd2bg2zargy44