Effects of intravenous administration of allogeneic mesenchymal stromal cells, derived from adipose tissue, in five dogs with chronic kidney disease
[Efeitos da administração intravenosa de células mesenquimais alogênicas, derivadas do tecido adiposo, em cinco cães com doença renal crônica]

M. Milistetd, C.Z. Cavalcante, H.S.S. Brunel, L.M.B. Leite, P.E. Mosko, P. F. Malard, P.V. Michelotto Júnior
2022 Arquivo Brasileiro de Medicina Veterinária e Zootecnia  
This study aimed to evaluate the safety of allogeneic adipose-derived mesenchymal stromal cell (aASC) treatment in dogs with chronic kidney disease (CKD) at the time of infusions and during the 120-day follow-up after the last infusion. Five dogs with CKD received three intravenous infusions of approximately 1×106?10% of aASCs per kilogram of body weight at 21-day intervals. Clinical and laboratory evaluations were performed at the time of each treatment and at 30 and 120 days after the last
more » ... usion. Adverse effects of the treatment were assessed using clinical observations, laboratory analyses, and owners' answers about their dog's behavior after infusions and during follow-up. The investigated animals did not present any adverse effects immediately after infusion or during the follow-up after the last infusion according to clinical and laboratory observations, as well as the dog owner's descriptions. One treated animal showed a reduction in creatinine, from 3.5mg/dL to 2.4mg/dL from day 0 to day 153, gained 100g of body weight, and improved disposition. The study results demonstrate that aASC therapy is safe for dogs with CKD; however, further studies are needed to investigate these promising results.
doi:10.1590/1678-4162-12392 fatcat:yys5l2o255bvxg65rk56zwfw6e