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TGF- 1 Downregulates AT1 Receptor Expression via PKC- -Mediated Sp1 Dissociation From KLF4 and Smad-Mediated PPAR- Association With KLF4
Arteriosclerosis, Thrombosis and Vascular Biology
Objective-Cardiovascular effects of angiotensin II are primarily mediated via the angiotensin II type 1 receptor (AT1R). Krüppel-like factor 4 (KLF4), a transcription factor that binds to the transforming growth factor (TGF)-␤ control element (TCE), regulates a variety of receptor expression in vascular smooth muscle cells. In the present study, we investigated the mechanisms of TGF-␤-mediated KLF4 regulation of AT1R expression. Methods and Results-Coimmunoprecipitation, chromatindoi:10.1161/atvbaha.111.244962 pmid:22282354 fatcat:okqrvv3dbbew3koap6rhdt5lom