Effects of Iranian Traditional Medicine Remedies (Apium Graveolence and Trachyspermum Copticum) on Modifying the Quality of Life in Patients with Functional Dyspepsia: A Double-Blind Randomized Clinical Trial Effects of Apium Graveolence and Trachyspermum Copticum on QOL of Patients with Functional Dyspepsia

Maryam Azimi, Mohammad Javad, Zahedi, Mitra Mehrabani, Haleh Tajadini, Farzaneh Zolala, Mohammad Baneshi, Rasool Choopani, Fariba Sharififar, Ali Asadipur, Mehdi Hayatbakhsh, Bijan Ahmadi (+3 others)
Functional dyspepsia (FD) is common digestive diseases affecting patients' quality of life (QOL). Recently, improving the patients' QOL is being considered as an important therapeutic objective; several studies have shown that traditional medicine is influential for FD patients improvement. The purpose of the present research was to investigate the effectiveness Iranian traditional medicine remedies on the QOL of patients with FD. Materials and Methods: Through double-blind randomized clinical
more » ... rial, our research patients were categorized into three groups followed as AT group(Apium graveolence 250 mg and Trachyspermum cop-ticum 250 mg, twice daily), placebo (cornstarch, 500 mg, twice daily), and (omeprazole 20 mg, daily)for a duration of one month and followed up for another one month. The patients' QOL was measured by Nepean Dyspepsia Index short-version questionnaire at the baseline, 4 and 8 weeks after treatment onset. Results: The patients QOL of AT group after 4 weeks was found to have improved significantly in comparison to those of omeprazole and placebo groups. The statistical difference between omeprazole and placebo groups was not significant. After 8 weeks, the difference between AT and placebo groups remained significant whereas the same was not clear between AT and omeprazole. Conclusion: Regarding our results, AT remedies could prove the FD patients' QOL more than omeprazole or placebo; therefore, it can be used as an adjuvant therapy for treatment of the disease.