DESIGNING A FEASIBLE METHOD TO PREDICT VANCOMYCIN TROUGH LEVELS IN PEDIATRIC POPULATION USING PATIENTS PARAMETERS

Ghada Elba, Ahmed El Mallah, Rana Itani, Nabila Droubi
2016 International Research Journal of Pharmacy  
The cost of measuring trough levels serves a barrier to many hospitals which affects drug monitoring, therefore a research directed towards designing a feasible method to predict vancomycin trough levels was conducted Methods: A retrospective study was conducted at AlMakassed General Hospital (MGH). MGH is a 240 bed tertiary teaching center in Beirut. Pediatric patient record admitted from January 2012 to March 2015 were retrieved. Forty five patients between the ages of 1 year and 12 years
more » ... ar and 12 years were included. Two methods were used to predict vancomycin trough levels using pharmacokinetic estimations. The predicted trough levels were calculated using vancomycin multiple dose equation. A third method using multiple regression analysis was conducted to predict vancomycin trough levels based on patients' characteristics. The percentage difference between the real and predicted trough level were calculated in all methods. Results: The multiple regression analysis conducted in those between 1 year and 12 years showed a coefficient of correlation of 0.85 between the trough levels and patients' parameters with a p-value < 0.001. Forty percent of the patients had a difference below 30 percent from the real trough level. An equation was concluded from the multiple regression analysis to predict trough levels and to design an appropriate dosage regimen. The multiple regression analysis was the only successful method in predicting appropriate trough levels based on patients' parameters.
doi:10.7897/2230-8407.0711120 fatcat:aob5h6slqrbudcnq7so7vsq5ke