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RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress
Adaptive responses to stress are essential for cell and organismal survival. In metazoans, little is known about the impact of environmental stress on RNA homeostasis. Results: By studying the regulation of a cadmium-induced gene named numr-1 in Caenorhabditis elegans, we discovered that disruption of RNA processing acts as a signal for environmental stress. We find that NUMR-1 contains motifs common to RNA splicing factors and influences RNA splicing in vivo. A genome-wide screen reveals thatdoi:10.1186/s12915-019-0675-z fatcat:gxt6tem255e5ri7ilu7s7lwm2u