Computational approach towards Identification of Functional Mutations in Il-6 Cytokine Family and It's Putative Association with Head and Neck Squamous Cell Carcinoma

Vijayashree Priyadharsini J, Assistant Professor, Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India.
2019 International Journal of Dentistry and Oral Science  
Objectives: The present study aimed to identify alterations in the IL-6 family to derive a putative association with HNSCC (head and neck squamous cell carcinoma). Subjects and Methods: Computational approaches have been used to find the functional mutation in the IL-6 family. The cBioportal database served as the primary source of data for analyzing the mutations. The TCGA (The Cancer Gene Atlas, Firehose legacy) dataset encompassing 504 samples of HNSCC patients were included in the study.
more » ... ults: Alterations were observed in CLCF1 (7%), CNTF (2.4%), CTF 1(0.2%), IL-6 (2.2%), IL-11 (0.8%), LTF (1%), OSM (0.6%) genes. Further, we found that three out of four mutations exhibited deleterious consequences, and one out of four missense variants exhibited neutral effect upon substitution of glycine with amino acid serine. Conclusion: Experimental validation is warranted to draw a strong association between the gene alterations and disease phenotype. Dental implication: Identification of genetic alterations in crucial genes would aid in the selection of genetic markers with strong association with HNSCC.
doi:10.19070/2377-8075-si02-06002 fatcat:yypsoigze5hu5ookthi6b2k6qq