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Many instances of cellular signaling and transcriptional regulation involve switchlike molecular responses to the presence or absence of input ligands. To understand how these responses come about and how they can be harnessed, we develop a statistical mechanical model to characterize the types of Boolean logic that can arise from allosteric molecules following the Monod-Wyman-Changeux (MWC) model. Building upon previous work, we show how an allosteric molecule regulated by two inputs candoi:10.1021/acs.jpcb.8b12517.s001 fatcat:mrnhje6g6zdxfartc2xl26kg44