BEDTools: The Swiss-Army Tool for Genome Feature Analysis

Aaron R. Quinlan
2014 Current Protocols in Bioinformatics  
Technological advances have enabled the use of DNA sequencing as a flexible tool to characterize genetic variation and to measure the activity of diverse cellular phenomena such as gene isoform expression and transcription factor binding. Extracting biological insight from the experiments enabled by these advances demands the analysis of large, multi-dimensional datasets. This unit describes the use of the BEDTools toolkit for the exploration of high-throughput genomics datasets. I present
more » ... al protocols for common genomic analyses and demonstrate how simple BEDTools operations may be combined to create bespoke pipelines addressing complex questions.
doi:10.1002/0471250953.bi1112s47 pmid:25199790 pmcid:PMC4213956 fatcat:axkbt6pwi5d23d2cdidkekgsx4