PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES EVALUATION OF ANTI ULCER ACTIVITY OF MIMOSA PUDICA ETHANOLIC EXTRACT IN RATS

Dharnendra Kumar, Ramesh, John Eienstien, Girish, Saleem
2011 unpublished
To evaluate ethanolic extracts of Mimosa pudica for its antiulcer activity in rats. Ethanol and indomethacin induced ulcers in rats model were used to evaluate antiulcer activity. Two doses of ethanolic extracts i.e. 250mg/kg and 500mg/kg were considered to evaluate anti-ulcer activity in both models. Scoring for ulcer was done as 0 for no ulcer, 1 for mild ulcer, and 2 for deep ulcer and volume of gastric acid secreted and its pH was also determined. In both the studies, there was no
more » ... re was no ulceration in saline treated group but in positive control group animals showed presence of deep ulcers, rise in gastric acid secretion and reduction pH. In both the models, animals treated with 250mg/kg EEMP shows mild ulcers, while animals treated with ranitidine and ethanolic extract of Mimosa pudica 500mg/kg (EEMP) shows no ulcers. EEMP (250mg/kg) showed slight reduction in gastric acid secretion but there was significant decrease in ranitidine and EEMP (250mg/kg) treated animals. Results obtained from above study suggest that the ethanolic extract of Mimosa pudica is having significant anti-ulcer activity.
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