Viral Modulation of Host Translation and Implications for Vaccine Development [chapter]

Abhijeet Bakre, Ralph A. Tripp
2018 Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics  
Translation of mRNAs into protein is an essential mechanism of regulating gene expression-and a step exploited by viruses for their own propagation. In this article, we review mechanisms that govern translation and provide an overview of the translation machinery, discuss some of the components involved in this process, and discuss how viruses modulate host translational controls and implications in vaccine design.
doi:10.5772/intechopen.72987 fatcat:6cqtg6kf6vdbhkvel6bdd2woie