and Objectives: Diabetes is one of the metabolic diseases in which various factors play a role. The aim of this study was to investigate the relationship between serum level of selenium and copper with insulin resistance (IR) in type 2 diabetes (T2D). Methods: This case control study was performed on 30 patients with T2D and 31 healthy individuals referred to Mashhad hospitals in 2020. The lipid profile, creatinine, uric acid, fasting blood sugar (FBS), HbA1c, blood pressure, smoking, exercise

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... n all patients were extracted from medical document. Insulin level measured by ELISA, and serum levels of copper and selenium measured with Atomic Absorption. IR level was calculated from HOMA-IR formula. Results: 30 T2D patients and 31 healthy individuals with a mean age of (52/3±10/4) and (50/4±10/2) years respectively, including 16 women in each group, were studied. BMI level (P=0/004), systolic pressure (P=0/031), FBS, HbA1c, insulin, selenium and copper levels and mean of IR in diabetic patients were significantly higher than the control group (P<0/001, each). Cholesterol, HDL, LDL, triglycerides, uric acid, creatinine, diastolic pressure, cigarettes and exercise were not significantly different between the two groups; But in the T2D group there is an inverse relationship between IR and cholesterol, HDL, LDL and systolic pressure (P< 0.05). In this group, IR increases with increasing selenium (P<0.001), while copper and IR were not significantly associated. Conclusion: According to these results, Selenium as an essential trace mineral, is associated with diabetes and IR and its control can help to control diabetes.